An economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy
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چکیده
Study population The parent study included women with an unruptured ectopic pregnancy, diagnosed by an algorithm using quantitative serum beta-human chorionic gonadotrophin (hCG) and transvaginal ultrasound, with or without a desire for future fertility. To be were eligible for the trial, the women had to have a serum beta-hCG concentration of less than 5,000 IU/L and an adnexal mass of less than 3.5 cm, with no foetal heart activity and minimal haemoperitoneum. The exclusion criteria included unstable vital signs, generalised peritonism, a falling serum beta-hCG, and diagnostic uncertainty requiring laparoscopy. Other exclusion criteria were an ultrasonically diagnosed interstitial, cervical, ovarian or heterotopic pregnancy, and contraindications to methotrexate or to laparoscopy. Further details were provided elsewhere (Sowter et al., see Other Publications of Related Interest).
منابع مشابه
مقایسه اثر درمانی تجویز متوترکسات تک دوز با دو دوز در درمان حاملگی خارج رحمی
Background & Aims: Ectopic pregnancy currently is the leading cause of pregnancy-related death during the first trimester. The methotrexate (MTX) was accepted as medical treatment and reduced surgery in unruptured ectopic pregnancy. Despite numerous studies, the best protocol for MTX treatment remains controversial. The present study compares single and two dose MTX administrations protocol in ...
متن کاملAn economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy.
OBJECTIVE To compare the direct and indirect costs of single dose systemic methotrexate with laparoscopic surgery for the treatment of unruptured ectopic pregnancy. DESIGN A cost minimisation study undertaken alongside a randomised trial. SETTING Departments of Obstetrics and Gynaecology in three hospitals in Auckland, New Zealand. PARTICIPANTS Sixty-two women with an ectopic pregnancy ra...
متن کاملFertility Outcome after Treatment of Unruptured Ectopic Pregnancy with Two Different Methotrexate Protocols
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Effect of Single-Dose Methotrexate Treatment on Ovarian Reserve in Women with Ectopic Pregnancy Undergoing Infertility Treatment: A Single-Center Experience
Background: The aim of this study was evaluation of the impact of single-dose methotrexate (MTX) treatment on ovarian reserve in women with ectopic pregnancy (EP) undergoing infertility treatment in Iranian population. Materials and Methods: This prospective cohort study was done between March 2015 and March 2017 in Tehran General Women Hospital, Tehran, Iran. We enrolled 20 patients with EP wh...
متن کاملMethotrexate provides significant cost savings for the treatment of unruptured ectopic pregnancy.
The aim of this study was to compare direct and indirect costs of single-dose methotrexate and laparoscopy in the treatment of unruptured ectopic pregnancy. We conducted a prospective study between 1 January 1995 and 31 May 1997 and recorded costs accrued from outpatient and inpatient treatment with methotrexate (group I) and laparoscopy (group II). We used the French National Social Security n...
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